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The Demise-o-Bomb is a weapon featured in the Spaceman Spiff universe. It was featured only once in Spaceman Spiff: Interplanetary Explorer Extraordinaire!. The bomb appears as a blue bomb with a poison symbol on it. Spiff was to throw the bomb, thinking it would kill the Naggon. However, it only stunned it. The Demise-o-Bomb was analogous to Calvin throwing a water balloon at his mother.

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